ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival

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ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival.

BACKGROUND Activated leucocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis and tumour progression of malignant melanoma and prostate cancer. AIMS To clarify the expression patterns of ALCAM in colon cancer and to correlate these with clinicopathological parameters, including patient survival. METHODS One hundred and eleven colorectal carcinomas were immunostained for...

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PURPOSE CD24 is a cell adhesion molecule that has been implicated in metastatic tumor progression of various solid tumors. We aimed to clarify the expression patterns of CD24 in colorectal cancer and to correlate these to clinicopathologic variables including patient survival. EXPERIMENTAL DESIGN 147 colorectal carcinomas and two colon carcinoma cell lines were immunostained for CD24. Cytopla...

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Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival

BACKGROUND Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) has recently been identified as an intestinal stem cell marker. In order to determine whether Lgr5 is a potential marker of cancer stem cells, we investigated whether Lgr5 expression correlated with Ki-67 expression and prognosis in colorectal carcinoma. METHODS Lgr5 and Ki-67 expression were evaluated by immunohist...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 2004

ISSN: 0021-9746

DOI: 10.1136/jcp.2004.016238